AZD 3965

Name	AZD3965
Synonyms	CS-2201 AZD3965 AZD-3965 AZD 3965 (S)-5-(4-hydroxy-4-methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 5-{[(4S)-4-Hydroxy-4-methyl-1,2-oxazolidin-2-yl]carbonyl}-1-isopropyl-3-methyl-6-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 5-[[(4S)-4-Hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-
CAS	1448671-31-5

Molecular Formula	C21H24F3N5O5S
Molar Mass	515.51
Density	1.483±0.06 g/cm3(Predicted)
Boling Point	723.1±70.0 °C(Predicted)
Solubility	DMSO: ≥ 36 mg/mL
pKa	10.92±0.50(Predicted)
Storage Condition	-20℃
Use	AZD3965 is a selective MCT1 inhibitor with a Ki value of 1.6 nM, which is 6 times higher than the selectivity of MCT2.
In vitro study	AZD3965 potently inhibits lactate transport and cell growth in lymphoma cell lines preferentially expressing mct1. AZD3965 inhibits MCT1 activity in cells and shows higher sensitivity in hypoxia. In H526,HGC27 cells and DMS114 cells, AZD3965 increased intracellular lactate and significantly decreased lactate uptake.
In vivo study	AZD3965(100 mg/kg,p.o.) reduced tumor growth and increased intratumoral lactate in non-obese diabetic SCID-γ mice bearing COR-L103 xenografts. In mice bearing H526 tumors, AZD3965(100 mg/kg, p.o.) caused increased lactate concentration, decreased growth, and increased radiosensitivity.

Last Update：2024-01-02 23:10:35

Use	AZD3965 is an effective, selective, the oral monocarboxylate transporter 1(MCT1) inhibitor has a binding affinity of 1.6 nM, which is 6 times higher than mct2.
biological activity	AZD3965 is a highly potent, selective and orally active monocarbolxylate transporter 1 (MCT1) the inhibitor, which has a binding affinity of 1.6 nM, is 6 times more selective than mct2. Phase 1.
Target	Value

Last Update：2024-04-10 22:29:15

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Product Name: AZD3965 Visit Supplier Webpage Request for quotation
CAS: 1448671-31-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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AZD 3965

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